The role of p-Stat3 Y705 immunohistochemistry in glioblastoma prognosis
作者: Sergiu SusmanRadu PîrlogDaniel LeucuțaAndrei Otto MitreVlad Adrian PadureanCarmen MelincoviciIoana MoldovanDoinița CrișanStefan Ioan Florian
刊名: Diagnostic Pathology, 2019, Vol.14 (1), pp.124
来源数据库: Springer Nature Journal
DOI: 10.1186/s13000-019-0903-4
关键词: GlioblastomaStat3ImmunohistochemistryPrognosis
原始语种摘要: In spite of the multimodal treatment used today, glioblastoma is still the most aggressive and lethal cerebral tumour. To increase survival in these patients, novel therapeutic targets must be discovered. Signal transducer and activator of transcription 3 (Stat3), a transcription factor that controls normal cell differentiation and survival is also involved in neoplastic celltransformation. In this study we evaluated the immunohistochemical expression of pY705-Stat3 in patients with primary glioblastoma and determined its prognostic role by correlating it with survival.
全文获取路径: Springer Nature  (合作)
影响因子:1.85 (2012)

  • glioblastoma 成胶质细胞瘤
  • prognosis 预报
  • survival 生存
  • aggressive 侵蚀的
  • transcription 地名转写
  • tumour 肿瘤
  • prognostic 预测的
  • correlating 关联
  • controls 控制机构
  • cerebral 大脑的