Multifaceted characterization of the signatures and efficacy of mesenchymal stem/stromal cells in acquired aplastic anemia
作者: Jiali HuoLeisheng ZhangXiang RenChengwen LiXingxin LiPeiyuan DongXuan ZhengJinbo HuangYingqi ShaoMeili GeJing ZhangMin WangNeng NiePeng JinYizhou Zheng
作者单位: 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, China
2The Postdoctoral Research Station, School of Medicine, Nankai University, 300071, Tianjin, China
刊名: Stem Cell Research & Therapy, 2020, Vol.11 (9), pp.581-594
来源数据库: Springer Nature Journal
DOI: 10.1186/s13287-020-1577-2
关键词: Acquired aplastic anemiaMSCsBiological phenotypeGenetic alterationsImmunodysregulation
原始语种摘要: Abstract(#br)Background(#br)Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate contribution to leukemia pathogenesis. However, the precise characteristics and alternation of MSCs during acquired aplastic anemia (AA) remain obscure. Methods(#br)In this study, we originally collected samples from both healthy donors (HD) and AA patients to dissect the hematological changes. To systematically evaluate the biological defects of AA-derived MSCs (AA-MSCs), we analyzed alterations in cellular morphology, immunophenotype, multi-lineage differentiation, cell migration, cellular apoptosis, and chromosome karyocyte, together with the immunosuppressive effect on the activation and...
全文获取路径: Springer Nature  (合作)
影响因子:3.652 (2012)