DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation
DNA甲基化与前列腺癌基因表达上调相关显示表观遗传调控的多样性
作者: Ieva RauluseviciuteFinn DrabløsMorten Beck Rye
作者单位: 1Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, P.O. Box 8905, NO-7491, Trondheim, Norway
2Clinic of Surgery, St. Olavs Hospital, Trondheim University Hospital, NO-7030, Trondheim, Norway
刊名: BMC Medical Genomics, 2020, Vol.13 (3), pp.E359-E386
来源数据库: Springer Nature Journal
DOI: 10.1186/s12920-020-0657-6
关键词: EpigeneticsDNA methylationProstate cancerGene expression
英文摘要: Abstract(#br)Background(#br)Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countries. Unlike several other types of cancer, PCa has few genetic drivers, which has led researchers to look for additional epigenetic and transcriptomic contributors to PCa development and progression. Especially datasets on DNA methylation, the most commonly studied epigenetic marker, have recently been measured and analysed in several PCa patient cohorts. DNA methylation is most commonly associated with downregulation of gene expression. However, positive associations of DNA methylation to gene expression have also been reported, suggesting a more diverse mechanism of epigenetic regulation. Such additional complexity could have important implications for understanding...
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影响因子:3.466 (2012)

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