Low dose of extracellular vesicles identified that promote recovery after ischemic stroke
作者: Laura Otero-OrtegaFernando Laso-GarcíaMari Carmen Gómez-de FrutosLuke DiekhorstArturo Martínez-ArroyoElisa Alonso-LópezMaría Laura García-BermejoMacarena Rodríguez-SerranoMercedes Arrúe-GonzaloExuperio Díez-TejedorBlanca FuentesMaría Gutiérrez-Fernández
作者单位: 1Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Autonomous University of Madrid, Paseo de la Castellana 261, 28046, Madrid, Spain
2Biomarkers and Therapeutic Targets Unit, Instituto Ramón y Cajal de investigación Sanitaria (IRYCIS), Madrid, Spain
刊名: Stem Cell Research & Therapy, 2020, Vol.11 (1), pp.175-513
来源数据库: Springer Nature Journal
DOI: 10.1186/s13287-020-01601-1
关键词: Brain repairExtracellular vesiclesOxygen and glucose deprivationSubcortical strokeWhite matter lesion
原始语种摘要: Abstract(#br)Background(#br)Mesenchymal stem cell-derived extracellular vesicles (EVs) are one of the most promising therapeutics in protective and/or regenerative therapy in animal models of stroke using a dose of 100 μg. However, whether EVs dose is related to outcomes is not known. This study aimed to identify the optimal effective dose of EVs from adipose tissue-derived mesenchymal stem cells that promote functional recovery in subcortical stroke. Materials and methods(#br)For this purpose, various doses of EVs were tested in an in vitro oxygen-glucose deprivation (OGD) model of oligodendrocytes and neuronal ischemia. At least 50 μg of EVs were necessary to induce proliferation and differentiation of oligodendrocyte and neurons in OGD conditions. For in vivo study, rats were subjected...
全文获取路径: Springer Nature  (合作)
影响因子:3.652 (2012)