Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
SDF-1 / CXCR4与SDF-1 / CXCR7在心脏干细胞迁移中的串扰
作者: Dong ChenYanli XiaKe ZuoYing WangShiying ZhangDong KuangYaqi DuanXia ZhaoGuoping Wang
作者单位: 1Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China
刊名: Scientific Reports, 2015, Vol.5 (1), pp.505-513
来源数据库: Springer Nature Journal
DOI: 10.1038/srep16813
英文摘要: Abstract(#br)Stromal cell-derived factor 1 (SDF-1) is a chemokine that can be expressed in injured cardiomyocytes after myocardial infarction (MI). By combining with its receptor CXCR4, SDF-1 induced stem and progenitor cells migration. CXCR7, a novel receptor for SDF-1, has been identified recently. We aimed to explore the roles of SDF-1/CXCR4 and SDF-1/CXCR7 pathway and their crosstalk in CSCs migration. In the present study, CXCR4 and CXCR7 expression were identified in CSCs. Transwell assay showed that SDF-1 caused CSCs migration in a dose- and time-dependent manner, which could be significantly suppressed by CXCR4 or CXCR7 siRNA. Phospho-ERK, phospho-Akt and Raf-1 significantly elevated in CSCs with SDF-1 stimulation. Knockdown of CXCR4 or CXCR7 significantly decreased phospho-ERK or...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)