ESR1 and EGF genetic variation in relation to breast cancer risk and survival
作者: Kristjana EinarsdóttirHatef DarabiYi LiYen Ling LowYu Qing LiCarine BonnardArvid SjölanderKamila CzeneSara WedrénEdison T LiuPer HallKeith HumphreysJianjun Liu
作者单位: 1Centre for Health Services Research, School of Population Health, University of Western Australia, 6009, Crawley, Perth, Western Australia
2Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 171 77, Stockholm, Sweden
3Human Genetics, Genome Institute of Singapore, 138672, Singapore
4Cancer Biology, Genome Institute of Singapore, 138672, Singapore
刊名: Breast Cancer Research, 2008, Vol.10 (1), pp.147-200
来源数据库: Springer Nature Journal
DOI: 10.1186/bcr1861
关键词: Breast CancerEpidermal Growth FactorBreast Cancer RiskBreast Cancer SurvivalBreast Cancer Case
原始语种摘要: Abstract(#br)Introduction(#br)Oestrogen exposure is a central factor in the development of breast cancer. Oestrogen receptor alpha (ESR1) is the main mediator of oestrogen effect in breast epithelia and has also been shown to be activated by epidermal growth factor (EGF). We sought to determine if common genetic variation in the ESR1 and EGF genes affects breast cancer risk, tumour characteristics or breast cancer survival. Methods(#br)We genotyped 157 single nucleotide polymorphisms (SNPs) in ESR1 and 54 SNPs in EGF in 92 Swedish controls and selected haplotype tagging SNPs (tagSNPs) that could predict both single SNP and haplotype variation in the genes with an R 2 of at least 0.8. The tagSNPs were genotyped in 1,590 breast cancer cases and 1,518 controls, and their...
全文获取路径: Springer Nature  (合作)
影响因子:5.872 (2012)