ushr: Understanding suppression of HIV in R
作者: Sinead E MorrisLuise Dziobek-GarrettAndrew J Yatesin collaboration with the EPIICAL Consortium
作者单位: 1Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA
刊名: BMC Bioinformatics, 2020, Vol.21 (21), pp.1736-1788
来源数据库: Springer Nature Journal
DOI: 10.1186/s12859-020-3389-x
关键词: HIVARTBiphasic decayMathematical modelR package
原始语种摘要: Abstract(#br)Background(#br)HIV/AIDS is responsible for the deaths of one million people every year. Although mathematical modeling has provided many insights into the dynamics of HIV infection, there is still a lack of accessible tools for researchers unfamiliar with modeling techniques to apply them to their own clinical data. Results(#br)Here we present ushr, a free and open-source R package that models the decline of HIV during antiretroviral treatment (ART) using a popular mathematical framework. ushr can be applied to longitudinal data of viral load measurements, and provides processing tools to prepare it for computational analysis. By mathematically fitting the data, important biological parameters can then be estimated, including the lifespans of short and long-lived infected...
全文获取路径: Springer Nature  (合作)
影响因子:3.024 (2012)