Expression of Interleukin-8 Receptor CXCR2 and Suppressor of Cytokine Signaling-3 in Astrocytic Tumors
白细胞介素-8受体CXCR2和细胞因子信号转导抑制因子-3在星形细胞瘤中的表达
作者: Penelope KorkolopoulouGeorgia LevidouElias A. El-HabrChristos AdamopoulosVassilis SamarasAthanasios ZisakisNikolaos KavantzasEfstathios BoviatsisParaskevi FragkouAthanasios G. PapavassiliouEfstratios PatsourisChristina Piperi
作者单位: 1First Department of Pathology, “Laiko” Hospital, University of Athens Medical School, 75 Mikras Asias Street, 11527, Athens, Greece
2Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
3Department of Pathology, “Red Cross” Hospital, Athens, Greece
4Department of Neurosurgery, University of Athens Medical School, “Evangelismos” Hospital, Athens, Greece
刊名: Molecular Medicine, 2012, Vol.18 (3), pp.379-388
来源数据库: Springer Nature Journal
DOI: 10.2119/molmed.2011.00449
英文摘要: Abstract(#br)The aim was to expand recently published information regarding the significance of the interleukin (IL)-8/p-STAT-3 (signal transducer and activator of transcription) pathway in astrocytomas, focusing on the IL-8 receptor, chemokine (C-X-C motif) receptor 2 (CXCR2), and the STAT-3 inhibitor SOCS-3 (suppressors of cytokine signaling). A total of 91 paraffin-embedded human astrocytoma tissues (grades II-IV) were investigated for the association of SOCS-3 and CXCR2 expression with clinicopathologic and morpho-metric microvascular characteristics, vascular endothelial growth factor (VEGF), IL-8 and p-STAT-3 expression and patient survival. Peripheral IL-8 secretion levels were assessed by enzyme-linked immunosorbent spot (ELISPOT). SOCS-3, p-STAT-3 and CXCR2 protein levels were...
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影响因子:4.469 (2012)

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