Analysis of association between common variants of uncoupling proteins genes and diabetic retinopathy in a Chinese population
解偶联蛋白基因常见变异与中国人群糖尿病视网膜病变的相关性分析
作者: Peiyao JinZhiqiang LiXian XuJiangnan HeJianhua ChenXun XuXuan DuXuelin BaiBo ZhangXiangui HeLina LuJianfeng ZhuYongyong ShiHaidong Zou
作者单位: 1Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (originally named“Shanghai First People’s Hospital”), Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, National Clinical Research Center for Eye Diseases, No.100 Haining Road, 20080, Shanghai, China
2Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 200030, Shanghai, China
3Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, 200040, Shanghai, China
4Xinjing Community Health Service Centre, 200335, Shanghai, China
刊名: BMC Medical Genetics, 2020, Vol.21 (2), pp.948-958
来源数据库: Springer Nature Journal
DOI: 10.1186/s12881-020-0956-y
关键词: Diabetic retinopathyUncoupling proteinsSingle nucleotide polymorphismsType 2 diabetes
英文摘要: Abstract(#br)Background(#br)The aim of this study was to explore the association between diabetic retinopathy (DR) and the variants of uncoupling proteins (UCPs) genes in a Chinese population of type 2 diabetes, in total and in patients of different glycemic status separately. Methods(#br)This case-control study included a total of 3107 participants from two datasets, among which 662 were DR patients (21.31%). Eighteen tag single nucleotide polymorphisms (SNPs) of UCP1 , UCP2 , and UCP3 were selected as genetic markers. TaqMan probes, Sequenom MassARRAY MALDI-TOF mass spectrometry platform and Affymetrix Genome-Wide Human SNP Array were used for genotyping. Online SHEsis software was used for association analysis. Bonferroni correction was used for multiple comparisons correction....
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影响因子:2.536 (2012)

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