Genetic characterization of HIV-1 epidemic in Anhui Province, China
作者: Dong ZhangJianjun WuYu ZhangYuelan ShenSheying DaiXiaolin WangHui XingJin LinJingwan HanJingyun LiYizu QinYongjian LiuLifeng MiaoBin SuHanping LiLin Li
作者单位: 1Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, 100071, Beijing, China
2Anhui Provincial Center for Disease Control and Prevention, 230601, Hefei, China
3State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, 102206, Beijing, China
刊名: Virology Journal, 2020, Vol.17 (2), pp.965-1948
来源数据库: Springer Nature Journal
DOI: 10.1186/s12985-020-1281-y
关键词: HIVSubtypesTransmission networkTransmitted drug resistance
英文摘要: Abstract(#br)Background(#br)Anhui Province in China is facing a severe HIV epidemic with an increasing number of newly diagnosed cases. Methods(#br)In this study, HIV genetic characteristics in the province were investigated. Newly reported HIV-positive individuals from 15 districts of Anhui Province were enrolled and interviewed. Total viral RNA was extracted from plasma isolated from blood samples. We amplified and sequenced an HIV pol fragment of the 1062 bp. The sequences were used for determination of HIV subtypes and the presence of drug resistance mutations. Transmission networks were constructed to explore possible relationships. And all of assembled partial pol genes were submitted to the Stanford HIV Drug Resistance Database website to find the transmitted drug resistance....
全文获取路径: Springer Nature  (合作)
影响因子:2.092 (2012)