Intravenous versus subcutaneous route pharmacokinetics of paracetamol (acetaminophen) in palliative care patients: study protocol for a randomized trial (ParaSCIVPallia)
作者: Marine VernantMarie LepoupetChristian CreveuilAntoine AlixCharlotte GourioLaure Peyro-Saint-PaulVeronique Lelong-BoulouardCyril Guillaumé
作者单位: 1Pain and Palliative Care Department and Regional Palliative Care Unit (RPCU) Maurice Abiven of Fondation de la Miséricorde, Caen University Hospital, CHU de Caen- avenue de la côte de Nacre, 14000, Caen, France
2Pain and Palliative Care Department, Caen University Hospital, 14000, Caen, France
3Caen University Hospital, Pharmacy, 14000, Caen, France
4Clinical Research Department, Caen University Hospital, 14000, Caen, France
刊名: Trials, 2020, Vol.21 (1), pp.208-219
来源数据库: Springer Nature Journal
DOI: 10.1186/s13063-019-3969-0
关键词: ParacetamolAcetaminophenSubcutaneous routeIntravenous routePharmacokineticsPalliative care
英文摘要: Abstract(#br)Background(#br)Among palliative care (PC) patients who are administered paracetamol, the subcutaneous (SC) route is often an alternative to the intravenous (IV) route. Yet pharmacological and clinical data on whether these are equivalent pharmacokinetically are lacking. Many French palliative teams are now empirically using paracetamol by the SC route, but there are no data to support this practice. This trial aims to compare the pharmacokinetic (PK) parameters of paracetomol between the IV and SC routes in PC patients. Methods/design(#br)This is a randomized, open, crossover study in two PC centers. The primary endpoints are AUC0-t, AUC0-∞, Cmax, Vd, and t1/2. All adverse events will be reported for a safety analysis. Twenty adult PC patients with an IV device having...
全文获取路径: Springer Nature  (合作)
影响因子:2.206 (2012)