Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?
作者: Ferdinando MannelloGiancarlo Gazzanelli
作者单位: 1Istituto di Istologia e Analisi di Laboratorio, Facoltà Scienze MFN Libera, Università Studi, 61029, Urbino, Italy
刊名: Breast Cancer Research, 2001, Vol.3 (4), pp.2021-2026
来源数据库: Springer Nature Journal
DOI: 10.1186/bcr302
关键词: BreastBreast cyst fluidCancerNipple aspirate fluidProstate-specific antigen
英文摘要: Abstract(#br)Since its identification, much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3]), a kallikrein-like serine protease that is the most valuable tumour marker for the screening, diagnosis and management of human prostate carcinoma. Recently, it has become widely accepted that PSA is also present in many nonprostatic sources, casting doubts about the specificity of its tissue expression. Here we summarize the findings on the biomolecular expression of PSA in breast secretions, cells and tissues of healthy and diseased females. Although several studies have strongly suggested that the molecular forms of PSA seem to represent a potential tool for the risk assessment of breast cancer, recent reports have yielded conflicting...
全文获取路径: Springer Nature  (合作)
影响因子:5.872 (2012)