Comparison of DNA methylation profiles from saliva in Coeliac disease and non-coeliac disease individuals
作者: Nerissa L. HearnChristine L. ChiuJoanne M. Lind
作者单位: 1Western Sydney University, School of Medicine, Sydney, Australia
2Macquarie University, Faculty of Medicine and Health Sciences, Sydney, Australia
刊名: BMC Medical Genomics, 2020, Vol.13 (1), pp.1099-1106
来源数据库: Springer Nature Journal
DOI: 10.1186/s12920-020-0670-9
关键词: Coeliac diseaseDNA methylationGluten-free dietSaliva
英文摘要: Abstract(#br)Background(#br)Coeliac disease (CD) is a autoimmune disease characterised by mucosal inflammation in the small intestine in response to dietary gluten. Genetic factors play a key role with CD individuals carrying either the HLA-DQ2 or HLA-DQ8 haplotype, however these haplotypes are present in half the general population making them necessary but insufficient to cause CD. Epigenetic modifications, including DNA methylation that can change in response to environmental exposure could help to explain how interactions between genes and environmental factors combine to trigger disease development. Identifying changes in DNA methylation profiles in individuals with CD could help discover novel genomic regions involved in the onset and development of CD. Methods(#br)The Illumina...
全文获取路径: Springer Nature  (合作)
影响因子:3.466 (2012)