Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study
作者: Nádia Calvo Martins OkuyamaFernando Cezar-dos-SantosÉrica Romão PereiraKleber Paiva TrugiloGuilherme Cesar Martelossi CebinelliMichelle Mota SenaAna Paula Lombardi PereiraAdriano Martin Felis AranomeLuis Fernando Lasaro MangieriRodolfo Sanches FerreiraMaria Angelica Ehara WatanabeKaren Brajão de Oliveira
作者单位: 10000 0001 2193 3537, grid.411400.0, Laboratory of molecular genetics and immunology, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil
20000 0001 2193 3537, grid.411400.0, Laboratory of study and application of DNA polymorphism, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil
刊名: Journal of Biomedical Science, 2018, Vol.25 (3), pp.1436-1447
来源数据库: Springer Nature Journal
DOI: 10.1186/s12929-018-0472-y
关键词: CXCL12Rs1801157 polymorphismHPV infectionCervical lesion
英文摘要: Abstract(#br)Background(#br)Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine. Methods(#br)In this study, 195...
全文获取路径: Springer Nature  (合作)
影响因子:2.458 (2012)