Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
作者: Salam Pradeep SinghKhumukcham NongalleimaNingthoujam Indrajit SinghPradip DoleyChingakham Brajakisor SinghThiyam Ramsing SinghDinabandhu Sahoo
作者单位: 1grid.464584.f, 0000 0004 0640 0101, Institute of Bioresources and Sustainable Development, Takyelpat, 795001, Imphal, Manipur, India
20000 0001 0675 2121, grid.411644.2, Department of Biotechnology, Manipur University, 795003, Canchipur, Manipur, India
刊名: Scientific Reports, 2018, Vol.8 (7), pp.231-43
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-018-22362-1
英文摘要: Abstract(#br)Zerumbone is a known anti-cancer herbal compound. However, the actual protein target is not fully understood or known. This investigation focus on the association of zerumbone in HCT116 colon cancer cell proliferation and its link with TNF-alpha. The study shows that with the increasing concentration of zerumbone, there was a reduction of HCT116 cells proliferation based on the cell line study and hence higher TNF-alpha inhibition based on the TNF-alpha assay. The study also emphasizes on the computational aspect by investigating the molecular docking analysis of zerumbone against TNF-alpha. The docked complex was further validated using molecular dynamics simulation studies. The docking analysis observed that alpha-beta unsaturated carbonyl scaffold is an important moiety...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)