Isolation of Ontario aquatic bird bornavirus 1 and characterization of its replication in immortalized avian cell lines
作者: Phuc H. PhamAlexander LeacyLi DengÉva NagyLeonardo Susta
作者单位: 1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
2Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
刊名: Virology Journal, 2020, Vol.17 (1), pp.2493-2504
来源数据库: Springer Nature Journal
DOI: 10.1186/s12985-020-1286-6
关键词: Avian bornavirusAquatic bird bornavirus-1ABBV-1 replication in avian cellsPersistent infectionImmortalized avian cell linesDuck embryo fibroblasts
原始语种摘要: Abstract(#br)Background(#br)Aquatic bird bornavirus 1 (ABBV-1) has been associated with neurological diseases in wild waterfowls. In Canada, presence of ABBV-1 was demonstrated by RT-qPCR and immunohistochemistry in tissues of waterfowls with history of neurological disease and inflammation of the central and peripheral nervous tissue, although causation has not been proven by pathogenesis experiments, yet. To date, in vitro characterization of ABBV-1 is limited to isolation in primary duck embryo fibroblasts. The objectives of this study were to describe isolation of ABBV-1 in primary duck embryonic fibroblasts (DEF), and characterize replication in DEF and three immortalized avian fibroblast cell lines (duck CCL-141, quail QT-35, chicken DF-1) in order to evaluate cellular permissivity...
全文获取路径: Springer Nature  (合作)
影响因子:2.092 (2012)