APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
APOE4与老年APOE小鼠对生物能量缺陷的不同区域脆弱性相关
作者: Estela Area-GomezDelfina LarreaMarta PeraRishi R. AgrawalDavid N. GuilfoyleLeila PirhajiKathleen ShannonHirra A. ArainArchana AshokQiuying ChenAllissa A. DillmanHelen Y. FigueroaMark R. CooksonSteven S. GrossErnest FraenkelKaren E. DuffTal Nuriel
作者单位: 1Department of Neurology, Columbia University, 630 West 168th Street, 10032, New York, NY, USA
2Institute of Human Nutrition, Columbia University, 630 West 168th Street, 10032, New York, NY, USA
3Department of Basic Sciences, Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya (UIC), 08195, Sant Cugat del Vallés, Spain
4Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute, 10962, Orangeburg, NY, USA
5Department of Biological Engineering, Massachusetts Institute of Technology, 350 Brookline Street, 02139, Cambridge, MA, USA
6Animal Facility, Nathan S. Kline Institute, 10962, Orangeburg, NY, USA
7Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, 630 West 168th Street, 10032, New York, NY, USA
8Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, 10032, New York, NY, USA
9Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, 10065, New York, NY, USA
10Cell Biolo
刊名: Scientific Reports, 2020, Vol.10 (Pt 2), pp.507-537
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-020-61142-8
英文摘要: Abstract(#br)The ε4 allele of apolipoprotein E ( APOE ) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association between APOE4 and AD remains unclear. While much of the research has focused on the ability of the apoE4 protein to increase the aggregation and decrease the clearance of Aβ, there is also an abundance of data showing that APOE4 negatively impacts many additional processes in the brain, including bioenergetics. In order to gain a more comprehensive understanding of APOE4 ′s role in AD pathogenesis, we performed a transcriptomics analysis of APOE4 vs. APOE3 expression in the entorhinal cortex (EC) and primary visual cortex (PVC) of aged APOE mice. This study revealed EC-specific upregulation of genes related to...
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影响因子:2.927 (2012)

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