Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway
依达拉奉通过Nrf2 / HO-1通路降低HMGB1和iNOS表达,减轻肺炎链球菌脑膜炎小鼠模型的海马损伤
作者: Zheng LiQian-qian MaYan YanFeng-dan XuXiao-ying ZhangWei-qin ZhouZhi-chun Feng
作者单位: 1grid.459338.0, 0000 0004 1756 6182, Department of Pediatrics, BaYi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital of Southern Medical University, 100700, Beijing, China
刊名: Acta Pharmacologica Sinica, 2016, Vol.37 (10), pp.1298-1306
来源数据库: Springer Nature Journal
DOI: 10.1038/aps.2016.71
关键词: Bacterial meningitisStreptococcus pneumoniaeEdaravoneHippocampusHMGB1INOSNrf2HO-1Neuroprotection
英文摘要: Abstract(#br)Aim:(#br)Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a free radical scavenger that has shown potent antioxidant, anti-inflammatory and neuroprotective effects in variety of disease models. In this study, we investigated whether edaravone produced neuroprotective actions in an infant mouse model of pneumococcal meningitis. Methods:(#br)C57BL/6 mice were infected on postnatal d 11 by intracisternal injection of a certain inoculum of Streptococcus pneumoniae . The mice received intracisternal injection of 10 μL of saline containing edaravone (3 mg/kg) once a day for 7 d. The severity of pneumococcal meningitis was assessed with a clinical score. In mice with severe meningitis, the survival rate from the time of infection to d 8 after infection was analyzed using...
全文获取路径: Springer Nature  (合作)