An in vivo brain–bacteria interface: the developing brain as a key regulator of innate immunity
作者: Celia Herrera-RinconJean-Francois ParéChristopher J. MartyniukSophia K. JannettyChristina HarrisonAlina FischerAlexandre DinisVishal KeshariRichard NovakMichael Levin
作者单位: 1Allen Discovery Center, and Department of Biology, Tufts University, Medford, MA, USA
2Center for Environmental and Human Toxicology and Department of Physiological Sciences, University of Florida, Gainesville, FL, USA
3Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA
刊名: npj Regenerative Medicine, 2020, Vol.5 (7), pp.1249-1270
来源数据库: Springer Nature Journal
DOI: 10.1038/s41536-020-0087-2
英文摘要: Abstract(#br)Infections have numerous effects on the brain. However, possible roles of the brain in protecting against infection, and the developmental origin and role of brain signaling in immune response, are largely unknown. We exploited a unique Xenopus embryonic model to reveal control of innate immune response to pathogenic E. coli by the developing brain. Using survival assays, morphological analysis of innate immune cells and apoptosis, and RNA-seq, we analyzed combinations of infection, brain removal, and tail-regenerative response. Without a brain, survival of embryos injected with bacteria decreased significantly. The protective effect of the developing brain was mediated by decrease of the infection-induced damage and of apoptosis, and increase of macrophage migration, as well...
全文获取路径: Springer Nature  (合作)
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