Evidence of compliance with and effectiveness of guidelines for noninvasive prenatal testing in China: a retrospective study of 189,809 cases
作者: Chan TianTao DengXiuhuang ZhuChen GongYangyu ZhaoYuan WeiRong LiXiufeng XuMiaonan HeZhiwei ZhangJing ChengMol BenWillemJie Qiao
作者单位: 1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191, Beijing, China
2National Clinical Research Center for Obstetrics and Gynecology, 100191, Beijing, China
3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, 100191, Beijing, China
4Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, 100191, Beijing, China
5Beijing CapitalBio Medical Laboratory, 101111, Beijing, China
6Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191, Beijing, China
7National Engineering Research Center for Beijing Biochip Technology, 102206, Beijing, China
8Department of Biomedical Engineering, Tsinghua University School of Medicine, 100084, Beijing, China
9Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia
10Beijing Advanced Innovation Center for Genomic, 100871, Beijing, China
11Peking-Tsinghua Center for Life Sc
刊名: Science China Life Sciences, 2020, Vol.63 (3), pp.319-328
来源数据库: Springer Nature Journal
DOI: 10.1007/s11427-019-9600-0
关键词: NIPTRisk for trisomyNIPT policy in ChinaPrenatal diagnosisMaternal age
英文摘要: Abstract(#br)In China, the medical guidelines recommend performing noninvasive prenatal testing (NIPT) with caution for pregnant women aged 35 years or older. However, the Mother and Child Health Care Law suggests that all primiparous women whose age is older than 35 years undergo prenatal diagnosis. These two inconsistent suggestions/recommendations have made obstetricians confused about whether to offer NIPT to these older pregnant women. To face this issue and find out the solution we performed a retrospective study of 189,809 NIPT samples collected from 28 provincial-leveled administrative units in China. Of 1,564 women with high-risk pregnancies who underwent NIPT, 459 (29.3%) did not participate in follow-up. The compound sensitivity and specificity of NIPT for trisomies 21, 18 and...
全文获取路径: Springer Nature  (合作)
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影响因子:2.024 (2011)

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