CXCR7 mediates TGFβ1-promoted EMT and tumor-initiating features in lung cancer
CXCR7介导TGF 21在肺癌中促进EMT和肿瘤启动特征
作者: Y-C WuS-J TangG-H SunK-H Sun
作者单位: 1Department of Biotechnology and Laboratory Science in Medicine, Department of Education and Research, National Yang-Ming University, Taipei City Hospital, Taipei, Taiwan
2grid.260664.0, 0000 0001 0313 3026, Institute of Marine Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
3Division of Urology, Department of Surgery, Tri-Service General Hospital and National Defense Medical Center, Taipei City, Taiwan
刊名: Oncogene, 2016, Vol.35 (16), pp.2123-2132
来源数据库: Springer Nature Journal
DOI: 10.1038/onc.2015.274
英文摘要: Abstract(#br)In the tumor microenvironment, chemokine system has a critical role in tumorigenesis and metastasis. The acquisition of stem-like properties by cancer cells is involved in metastasis and drug resistance, which are pivotal problems that result in poor outcomes in patients with lung cancer. Patients with advanced lung cancer present high plasma levels of transforming growth factor-β1 (TGFβ1), which correlate with poor prognostic features. Therefore, TGFβ1 may be important in the tumor microenvironment, where chemokines are widely expressed. However, the role of chemokines in TGFβ1-induced tumor progression still remains unclear. In our study, TGFβ1 upregulated CXC chemokine receptor expression, migration, invasion, epithelial–mesenchymal transition (EMT) and cancer stem...
全文获取路径: Springer Nature  (合作)
影响因子:7.357 (2012)