Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine–inflammation interactions
作者: Qiansheng HuangYajie ChenQionghua ChenHuanteng ZhangYi LinMaobi ZhuSijun Dong
作者单位: 1Chinese Academy of Sciences
2The First Affiliated Hospital of Xiamen University
刊名: Archives of Toxicology, 2017, Vol.91 (4), pp.1915-1924
来源数据库: Springer Nature Journal
DOI: 10.1007/s00204-016-1854-0
关键词: Polychlorinated biphenylsEndometriosisHSD17B7LXA4Methylation
原始语种摘要: Polychlorinated biphenyls (PCBs) contain 209 congeners with various structure–activities. Exposure to PCBs was related to disorders of female reproduction. Endometriosis (EM) is an estrogen- and inflammation-dependent disease with high prevalence and severe health outcomes. Epidemiological studies have shown the effects of PCBs exposure on EM in regard to various structures of PCBs. However, little evidence is available from the toxicology considering the structure of PCBs. In the study, environmentally relevant concentrations of PCBs were used to treat primary cultured endometrial cells and an EM mouse model. Dioxin-like CB126, but not non-dioxin-like CB153, significantly enhanced 17β-estradiol (E2) biosynthesis in a dose-dependent manner. Among the genes related to estrogen metabolism,...
全文获取路径: Springer Nature  (合作)
影响因子:5.215 (2012)

  • rather 宁愿
  • inflammation 炎症
  • triggered 触发的
  • development 开发
  • biosynthesis 生物合成
  • expression 表示
  • indirectly 间接地
  • available 可供应的
  • observed 观察到的
  • increased 增加