Model-based exploration of the impact of glucose metabolism on the estrous cycle dynamics in dairy cows
作者: Mohamed OmariAlexander LangeJulia PlöntzkeSusanna Röblitz
作者单位: 1Computational Systems Biology Group, Zuse Institute Berlin, Takustr. 7, Berlin, Germany
2Department of Applied Biosciences and Process Engineering, Anhalt University of Applied Sciences, Bernburger Str. 55, 06366, Köthen, Germany
3Computational Biology Unit, University of Bergen, Department of Informatics, Thormøhlensgate 55, 5008, Bergen, Norway
刊名: Biology Direct, 2020, Vol.15 (8), pp.4022-32
来源数据库: Springer Nature Journal
DOI: 10.1186/s13062-019-0256-7
关键词: Systems biologyMathematical modellingOrdinary differential equationsMetabolismNutritionBovineFertilityReproductionLactationHormonesFollicles
英文摘要: Abstract(#br)Background(#br)Nutrition plays a crucial role in regulating reproductive hormones and follicular development in cattle. This is visible particularly during the time of negative energy balance at the onset of milk production after calving. Here, elongated periods of anovulation have been observed, resulting from alterations in luteinizing hormone concentrations, likely caused by lower glucose and insulin concentrations in the blood. The mechanisms that result in a reduced fertility are not completely understood, although a close relationship to the glucose-insulin metabolism is widely supported. Results(#br)Following this idea, we developed a mathematical model of the hormonal network combining reproductive hormones and hormones that are coupled to the glucose compartments...
全文获取路径: Springer Nature  (合作)
影响因子:2.72 (2012)