Identifying the effect of patient sharing on between-hospital genetic differentiation of methicillin-resistant Staphylococcus aureus
作者: Hsiao-Han ChangJanina DordelTjibbe DonkerColin J. WorbyEdward J. FeilWilliam P. HanageStephen D. BentleySusan S. HuangMarc Lipsitch
作者单位: 1Harvard T.H. Chan School of Public Health
2Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
3Drexel University
4University of Oxford
5University of Bath
6University of California Irvine School of Medicine
刊名: Genome Medicine, 2016, Vol.8 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13073-016-0274-3
关键词: Genetic differentiationPatient sharingGene flowTransmissionStaphylococcus aureus
英文摘要: Abstract(#br) Background(#br)Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected 2,214 samples from 30 hospitals in Orange County, California and showed by spa typing that genetic differentiation decreased significantly with increased patient sharing. In the current study, we focused on the 986 samples with spa type t008 from the same population.(#br) Methods(#br)We used genome sequencing to determine the effect of patient sharing on genetic differentiation between hospitals. Genetic differentiation was measured by between-hospital genetic diversity, F ST , and the proportion of nearly identical isolates between...
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影响因子:3.397 (2012)

  • methicillin 6二甲氧基苯青霉素
  • hospital 医院
  • resistant 耐久的
  • effect 效应
  • sharing 共用
  • genetic 遗传的
  • patient 有耐性的
  • between 在中间