Enhancing effectiveness of capillary electrophoresis as an analytical tool in the supramolecular acidity modification
作者: Paweł Mateusz NowakMichał WoźniakiewiczMagdalena JanusPaweł Kościelniak
作者单位: 1Jagiellonian University in Kraków
刊名: Analytical and Bioanalytical Chemistry, 2017, Vol.409 (14), pp.3633-3643
来源数据库: Springer Nature Journal
DOI: 10.1007/s00216-017-0305-y
关键词: Capillary electrophoresisCapillary coatingCyclodextrinsHost-guest complexesJoule heatingP K a shift
英文摘要: A strategic modification of acidity (p K a values) by the non-covalent host-guest interactions is one of the most promising concepts in current supramolecular chemistry. This work is aimed at enhancing the effectiveness of capillary electrophoresis (CE) in determination of p K a shifts caused by such interactions and their thermal dependencies crucial in a deep thermodynamic description. We show how to (i) minimize the systematic errors related to Joule heating, (ii) minimize the influence of a voltage ramp time, (iii) speed up p K a shift identification and estimation, (iv) interpret thermal effects related to two overlapped dynamic equilibria, and (v) determine p K a shifts by an alternative spectrophotometric method (CE-DAD). The proposed...
原始语种摘要: A strategic modification of acidity (p K a values) by the non-covalent host-guest interactions is one of the most promising concepts in current supramolecular chemistry. This work is aimed at enhancing the effectiveness of capillary electrophoresis (CE) in determination of p K a shifts caused by such interactions and their thermal dependencies crucial in a deep thermodynamic description. We show how to (i) minimize the systematic errors related to Joule heating, (ii) minimize the influence of a voltage ramp time, (iii) speed up p K a shift identification and estimation, (iv) interpret thermal effects related to two overlapped dynamic equilibria, and (v) determine p K a shifts by an alternative spectrophotometric method (CE-DAD). The proposed...
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:3.659 (2012)

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关键词翻译
关键词翻译
  • supramolecular 超分子的
  • cyclodextrin 环糊精
  • modification 诱发变异
  • thermodynamic 热力学的
  • acidity 酸度
  • structurally 在结构上
  • effectiveness 有效性
  • capillary 毛状的
  • exothermic 产热的
  • examine