The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage
作者: Lokendra ChandPrabodh RisalNirajan ShresthaDhruba AcharyaYae Sul JeongChan Young KimYeon Jun Jeong
作者单位: 1Laboratory of Liver Regeneration, Biomedical Research Institute, Chonbuk National University Medical School
2Department of Biochemistry, Kathmandu University School of Medical Sciences
3Department of Microbiology, Kathmandu University School of Medical Sciences
4Department of Pediatrics, Elmhurst Hospital
5Department of Surgery, Chonbuk National University Hospital
6Department of Pediatrics, Icahn School of Medicine at Mount Sinai
刊名: Molecular & Cellular Toxicology, 2018, Vol.14 (3), pp.263-272
来源数据库: Springer Nature Journal
DOI: 10.1007/s13273-018-0029-x
关键词: 35-diethoxycarbonyl-14-dihydro-collidineOrthotopic liver transplantationHepatocyte transplantation
原始语种摘要: Abstract(#br) Backgrounds(#br)Orthotopic Liver Transplantation (OLT) is the therapy of choice for the treatment of end-stage liver disease, but the severe shortage of organ donors, complex and expensive surgical procedure and increased mortality of prospective organ recipient limit the use of OLT. To overcome this problem the technique of hepatocyte transplantation has been considered as an alternative to OLT. Hepatocyte transplantation is less invasive, cost effective cryo-preservable and can be distributed from single donor to multiple recipients. In this study we have established and characterize the hepatocyte cell line possessing the morphological and functional characteristics of hepatocytes from chemically injured liver. Hence we hypothesized that the hepatocyte cell line derived...
全文获取路径: Springer Nature  (合作)
影响因子:0.72 (2012)