Upregulation of the transcription factor TFAP2D is associated with aggressive tumor phenotype in prostate cancer lacking the TMPRSS2:ERG fusion
作者: Christoph FrauneLuisa HarmsFranziska BüscheckDoris HöflmayerMaria Christina TsourlakisTill S. ClauditzRonald SimonKatharina MöllerAndreas M. LuebkeChristina Möller-KoopStefan SteurerClaudia Hube-MaggGuido SauterSören WeidemannPatrick LebokDavid DumSimon KindSarah MinnerJakob R. IzbickiThorsten SchlommHartwig HulandHans HeinzerEike BurandtAlexander HaeseMarkus GraefenCornelia Schroeder
作者单位: 1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany
2General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
3Department of Urology, Charité - Universitätsmedizin Berlin, Berlin, Germany
4Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
刊名: Molecular Medicine, 2020, Vol.26 (1), pp.1252-1259
来源数据库: Springer Nature Journal
DOI: 10.1186/s10020-020-00148-4
关键词: TFAP2DProstate cancerGenomic instabilityPrognosisImmunohistochemistryTissue micro array
英文摘要: Abstract(#br)Background(#br)TFAP2D is a transcription factor important for modulating gene expression in embryogenesis. Its expression and prognostic role in prostate cancer has not been evaluated. Methods(#br)Therefore, a tissue microarray containing 17,747 prostate cancer specimens with associated pathological, clinical, and molecular data was analyzed by immunohistochemistry to assess the role of TFAP2D. Results(#br)TFAP2D expression was typically increased in prostate cancer as compared to adjacent non-neoplastic glands. TFAP2D staining was considered negative in 24.3% and positive in 75.7% of 13,545 interpretable cancers. TFAP2D staining was significantly linked to advanced tumor stage, high classical and quantitative Gleason grade, lymph node metastasis, and a positive surgical...
全文获取路径: Springer Nature  (合作)
影响因子:4.469 (2012)