Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin
作者: I. LevingerT. C. Brennan-SperanzaA. ZulliL. ParkerX. LinJ.R. LewisB. B. Yeap
作者单位: 1Victoria University
2University of Sydney
3The University of Sydney
4University of Western Australia
5Fiona Stanley Hospital
刊名: Osteoporosis International, 2017, Vol.28 (8), pp.2265-2273
来源数据库: Springer Nature Journal
DOI: 10.1007/s00198-017-3994-3
关键词: Cardiovascular diseaseGlucose uptakeInsulin sensitivityOsteocalcin
原始语种摘要: Undercarboxylated osteocalcin (ucOC) may play a role in glucose homeostasis and cardiometabolic health. This review examines the epidemiological and interventional evidence associating osteocalcin (OC) and ucOC with metabolic risk and cardiovascular disease. The complexity in assessing such correlations, due to the observational nature of human studies, is discussed. Several studies have reported that higher levels of ucOC and OC are correlated with lower fat mass and HbA1c. In addition, improved measures of glycaemic control via pharmacological and non-pharmacological (e.g. exercise or diet) interventions are often associated with increased circulating levels of OC and/or ucOC. There is also a relationship between lower circulating OC and ucOC and increased measures of vascular...
全文获取路径: Springer Nature  (合作)
影响因子:4.039 (2012)

  • osteocalcin 骨钙素
  • cardiovascular 心血管的
  • muscle 肌肉
  • metabolic 新陈代谢的
  • insulin 胰岛素
  • observational 观察的
  • menopausal 绝经期的
  • homeostasis 体内平衡
  • relationship 关系
  • increased 增加