HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway
作者: Mariela Natacha GonzálezWallace de MelloGillian S. Butler-BrowneSuse Dayse Silva-BarbosaVincent MoulyWilson SavinoIngo Riederer
作者单位: 1Oswaldo Cruz Foundation
2Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM)
3Sorbonne Universités, Université Pierre et Marie Curie, INSERM UMRS974, CNRS FRE3617, Center for Research in Myology
4National Cancer Institute (INCA)
刊名: Skeletal Muscle, 2017, Vol.7 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13395-017-0138-6
关键词: Myoblast transplantationHGFMigrationLamininFibronectinMatrix metalloproteinasesMAPK/ERK
英文摘要: The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a soluble factor during muscle regeneration, along with extracellular matrix (ECM) molecules. In this study, we aimed at determining whether HGF is able to interact with ECM proteins, particularly laminin 111 and fibronectin, and to modulate human myoblast migration.
原始语种摘要: The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a soluble factor during muscle regeneration, along with extracellular matrix (ECM) molecules. In this study, we aimed at determining whether HGF is able to interact with ECM proteins, particularly laminin 111 and fibronectin, and to modulate human myoblast migration.
全文获取路径: Springer Nature  (合作)
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关键词翻译
关键词翻译
  • migration 迁移
  • pathway 轨道
  • human 人的
  • extracellular 胞外的
  • muscle 肌肉
  • involvement 财政困难
  • Laminin 昆布氨酸
  • matrix 石基
  • driven 从动的
  • regeneration 再生