Regulation of human airway smooth muscle cell migration and relevance to asthma
作者: Brittany SalterCara PrayKatherine RadfordJames G. MartinParameswaran Nair
作者单位: 1Firestone Institute for Respiratory Health, St Joseph’s Healthcare and Department of Medicine
2Meakins Christie Laboratories, McGill University
刊名: Respiratory Research, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12931-017-0640-8
关键词: Airway smooth muscleMigrationAsthmaCytokinesRemodelling
英文摘要: Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the migration of airway smooth muscle cells may contribute to cellular hyperplasia, and thus increased airway smooth muscle mass. The precise source of these cells remains unknown. Increased airway smooth muscle mass may be collectively due to airway infiltration of myofibroblasts, neighbouring airway smooth muscle cells in the bundle, or circulating hemopoietic progenitor cells. However, the relative contribution of each cell type is not well understood. In addition, although many studies have identified pro and anti-migratory agents of airway smooth muscle cells, whether these agents...
原始语种摘要: Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the migration of airway smooth muscle cells may contribute to cellular hyperplasia, and thus increased airway smooth muscle mass. The precise source of these cells remains unknown. Increased airway smooth muscle mass may be collectively due to airway infiltration of myofibroblasts, neighbouring airway smooth muscle cells in the bundle, or circulating hemopoietic progenitor cells. However, the relative contribution of each cell type is not well understood. In addition, although many studies have identified pro and anti-migratory agents of airway smooth muscle cells, whether these agents...
全文获取路径: Springer Nature  (合作)
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影响因子:3.642 (2012)

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关键词翻译
关键词翻译
  • airway 航路
  • asthma 哮喘
  • muscle 肌肉
  • smooth 平滑的
  • migration 迁移
  • remodelling 重装
  • increased 增加
  • hemopoietic 生血的
  • remains 残渣
  • evidence