IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma
来源于癌相关成纤维细胞的IL6通过CXCR7促进食管鳞癌化疗耐药
作者: Y QiaoC ZhangA LiD WangZ LuoY PingB ZhouS LiuH LiD YueZ ZhangX ChenZ ShenJ LianY LiS WangF LiL HuangL WangB ZhangJ YuZ QinY Zhang
作者单位: 1grid.412633.1, Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2grid.412633.1, Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
3grid.207374.5, 0000 0001 2189 3846, School of Life Sciences, Zhengzhou University, Zhengzhou, China
4grid.16753.36, 0000 0001 2299 3507, Department of Hematology/Oncology, School of Medicine, Northwestern University, Chicago, IL, USA
5grid.24827.3b, 0000 0001 2179 9593, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
6grid.412633.1, Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
7Key Laboratory for Tumor Immunology and Biotherapy of Henan Province, Zhengzhou, China
刊名: Oncogene, 2018, Vol.37 (7), pp.873-883
来源数据库: Springer Nature Journal
DOI: 10.1038/onc.2017.387
英文摘要: Abstract(#br)Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived mainly from cancer-associated fibroblasts played the most important role in chemoresistance by upregulating C-X-C motif chemokine receptor 7 (CXCR7) expression through signal transducer and activator of transcription 3/nuclear factor-κB pathway. CXCR7 knockdown resulted in the inhibition of IL6-induced proliferation and chemoresistance. In addition, CXCR7 silencing significantly decreased gene expression associated with stemness, chemoresistance and...
全文获取路径: Springer Nature  (合作)
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影响因子:7.357 (2012)

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