Endothelial CXCR7 regulates breast cancer metastasis
内皮CXCR7调节乳腺癌转移
作者: A C StacerJ FennerS P CavnarA XiaoS ZhaoS L ChangA SalomonnsonK E LukerG D Luker
作者单位: 1grid.214458.e, 0000000086837370, Department of Radiology, University of Michigan Center for Molecular Imaging, University of Michigan Medical School and College of Engineering, Ann Arbor, MI, USA
2grid.214458.e, 0000000086837370, Department of Biomedical Engineering, University of Michigan Medical School and College of Engineering, Ann Arbor, MI, USA
3grid.214458.e, 0000000086837370, Department of Radiation Oncology, University of Michigan Medical School and College of Engineering, Ann Arbor, MI, USA
4Depatment of Chemical Engineering, University of Michigan Medical School and College of Engineering, Ann Arbor, MI, USA
5grid.214458.e, 0000000086837370, Department of Microbiology and Immunology, University of Michigan Medical School and College of Engineering, Ann Arbor, MI, USA
刊名: Oncogene, 2016, Vol.35 (13), pp.1716-1724
来源数据库: Springer Nature Journal
DOI: 10.1038/onc.2015.236
英文摘要: Abstract(#br)Atypical chemokine receptor CXCR7 (ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple steps in tumor growth and metastasis in breast cancer and multiple other malignancies. Although normal vascular endothelium expresses low levels of CXCR7, marked upregulation of CXCR7 occurs in tumor vasculature in breast cancer and other tumors. To investigate effects of endothelial CXCR7 in breast cancer, we conditionally deleted this receptor from vascular endothelium of adult mice, generating CXCR7ΔEND/ΔEND animals. CXCR7ΔEND/ΔEND mice appeared phenotypically normal, although these animals exhibited a modest 35±3% increase in plasma CXCL12 as compared with control. Using two different syngeneic, orthotopic tumor...
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:7.357 (2012)

×