Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways
作者: Md. Akil HossainSeung-Jin LeeNa-Hye ParkAbraham Fikru MechessoBiruk Tesfaye BirhanuJeongWoo KangMd. Ahsanur RezaJoo-Won SuhSeung-Chun Park
作者单位: 10000 0001 0661 1556, grid.258803.4, Laboratory of Clinical Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, 702-701, Daegu, Republic of Korea
20000 0004 1798 4034, grid.466502.3, Veterinary drugs & Biologics Division, Animal and Plant Quarantine Agency (QIA), 177, Hyeoksin 8-ro, 39660, Gimcheon-si, Gyeongsangbuk-do, Republic of Korea
3grid.443081.a, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University (Outer Campus), 8210, Babugonj, Barisal, Bangladesh
40000 0001 2339 0388, grid.410898.c, Center for Nutraceutical and Pharmaceutical Materials, Division of Bioscience and Bioinformatics, Science campus, Myongji University, 449-728, Yongin, Gyeonggi, Republic of Korea
刊名: Scientific Reports, 2017, Vol.7 (1), pp.197-222
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-017-10997-5
英文摘要: Abstract(#br)Quorum sensing (QS) is a cell density-dependent regulation of virulent bacterial gene expression by autoinducers that potentially pertains in the epidemic of bacterial virulence. This study was initially designed to evaluate the effect of 5 phenolic compounds in the modulation of QS and virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa , and to determine the mechanisms of their effects. Biosensor strains were used to assess antibacterial and anti-QS effect of these compounds. Only methyl gallate (MG) among these compounds demonstrated profound anti-QS effect in the preliminary study, and thus only MG was utilized further to evaluate the effects on the synthesis and activity of acyl homoserine lactone (AHL) in C. violaceum and on the modulation of...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)