Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement
作者: Angelina SchwarzKatja Möller-HackbarthLwaki EbarasiDavid Unnersjö JessSonia ZambranoHans BlomAnnika WernersonMark LalJaakko Patrakka
作者单位: 1Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
2Science for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Solna, Sweden
3Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
4Bioscience, Cardiovascular, Renal and Metabolism, Innovative Medicines Biotech Unit, AstraZeneca, Gothenburg, Sweden
刊名: Scientific Reports, 2019, Vol.9 (12), pp.2607-2614
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-019-45303-y
英文摘要: Abstract(#br)Podocytes have an important role in the pathogenesis of diabetic nephropathy (DN). Podocyte foot process effacement, mediated largely by the actin-based cytoskeleton of foot processes, is commonly detected in DN and is believed to be a key pathogenic event in the development of proteinuria. In this study, we identified coronin 2b (Coro2b), a member of known actin-regulating proteins, the coronins, as a highly podocyte-enriched molecule located at the cytoplasmic side of the apical plasma membrane. Studies in human renal biopsies show that glomerular Coro2b expression is significantly down-regulated in patients with DN. Studies in knockout mice indicate that Coro2b is not required for the development or maintenance of the glomerular filtration barrier. Moreover, inactivation...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)