Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption
作者: Alyx VogleTongqi QianShijia ZhuElizabeth BurnettHolger FeyZhibin ZhuAli KeshavarzianMaliha ShaikhYujin HoshidaMiran KimCostica Aloman
作者单位: 1Division of Digestive Diseases and Nutrition, Section of Hepatology, Rush University, Chicago, IL, USA
2University of Texas Southwestern Medical Center, Division of Digestive Diseases, Department of Internal Medicine, Texas, USA
刊名: Scientific Reports, 2020, Vol.10 (4), pp.638-644
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-020-59188-9
英文摘要: Abstract(#br)Murine models of chronic alcohol consumption are frequently used to investigate alcoholic liver injury and define new therapeutic targets. Lieber-DeCarli diet (LD) and Meadows-Cook diet (MC) are the most accepted models of chronic alcohol consumption. It is unclear how similar these models are at the cellular, immunologic, and transcriptome levels. We investigated the common and specific pathways of LD and MC models. Livers from LD and MC mice were subjected to histologic changes, hepatic leukocyte population, hepatic transcripts level related to leukocyte recruitment, and hepatic RNA-seq analysis. Cross-species comparison was performed using the alcoholic liver disease (ALD) transcriptomic public dataset. Despite LD mice have increased liver injury and steatosis by alcohol...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)