Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer
作者: Yuanyuan GuShuoxin LiuXiaodan ZhangGuimin ChenHongwei LiangMengchao YuZhicong LiaoYong ZhouChen-Yu ZhangTao WangChen WangJunfeng ZhangXi Chen
作者单位: 1Nanjing University
2Linyi Tumor Hospital
3Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University and Nanjing Multi-Center Biobank
刊名: Protein & Cell, 2017, Vol.8 (6), pp.455-466
来源数据库: Springer Nature Journal
DOI: 10.1007/s13238-017-0393-7
关键词: MicroRNAMTUS1MiR-19a/bLung cancerProliferationMigration
英文摘要: MTUS1 (microtubule-associated tumor suppressor 1) has been identified that can function as a tumor suppressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b (miR-19a/b) promote proliferation and migration of lung cancer cells by targeting MTUS1. First, MTUS1 was proved to function as a tumor suppressor in lung cancer and was linked to cell proliferation and migration promotion. Second, an inverse correlation between miR-19a/b expression and MTUS1 mRNA/protein expression was noted in human lung cancer tissues. Third, MTUS1 was appraised as a direct target of miR-19a/b by bioinformatics analysis. Fourth, direct MTUS1 regulation by miR-19a/b in lung cancer cells was...
原始语种摘要: MTUS1 (microtubule-associated tumor suppressor 1) has been identified that can function as a tumor suppressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b (miR-19a/b) promote proliferation and migration of lung cancer cells by targeting MTUS1. First, MTUS1 was proved to function as a tumor suppressor in lung cancer and was linked to cell proliferation and migration promotion. Second, an inverse correlation between miR-19a/b expression and MTUS1 mRNA/protein expression was noted in human lung cancer tissues. Third, MTUS1 was appraised as a direct target of miR-19a/b by bioinformatics analysis. Fourth, direct MTUS1 regulation by miR-19a/b in lung cancer cells was...
全文获取路径: Springer Nature  (合作)
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影响因子:3.22 (2012)

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关键词翻译
关键词翻译
  • migration 迁移
  • expression 表示
  • regulate 控制
  • bioinformatics 生物信息学
  • promote 助长
  • suppressor 抑制栅
  • cancer 癌症
  • transfection 转染
  • targeting 导向目标
  • luciferase 荧光素酶