Anti-hyperglycemic and anti-hyperlipidemia effects of the alkaloid-rich extract from barks of Litsea glutinosa in ob/ob mice
作者: Xiaopo ZhangYan JinYounan WuCaiyun ZhangDejun JinQingxia ZhengYoubin Li
作者单位: 10000 0004 0368 7493, grid.443397.e, School of Pharmaceutical Science, Hainan Medical University, 571199, Haikou, China
2Zhengzhou Tobacco Research Institute, 450001, Zhengzhou, China
刊名: Scientific Reports, 2018, Vol.8 (1), pp.439-441
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-018-30823-w
原始语种摘要: Abstract(#br)The present study investigated the anti-hyperglycemic and anti-hyperlipidemia effects of the alkaloid-rich extract from Litsea glutinosa barks (CG) in ob/ob mice. CG was orally administrated (50, 100 and 200 mg/kg) to ob/ob mice for 4 weeks. Parameters of glucose metabolism, hepatotoxicity, hyperlipidemia and inflammation were measured. CG was chemically characterized using UPLC-QTOF-MS. CG dose-dependently decreased body and fat weights without reducing average food intake. CG (100–200 mg/kg) significantly reduced the serum levels of fasting glucose, glycosylated hemoglobin (HbAlc) and glycosylated serum protein (GSP). CG increased insulin sensitivity as manifested by decreased fasting serum insulin, reduced homeostasis model assessment-estimated insulin resistance...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)