Apelin affects the mouse aging urinary peptidome with minimal effects on kidney
作者: Claire VinelJoost P. SchanstraFranck BoizardOphélie PéreiraJohanna AuriauAlizée DortignacBenjamin BreuilGuylène FeuilletEsther Nkuipou-KenfackPetra ZürbigPhilippe ValetJean-Loup BascandsCédric DrayColette Denis
作者单位: 1Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France
2Université Toulouse III Paul-Sabatier, Toulouse, France
3Mosaiques diagnostics GmbH, Hannover, Germany
4Institut National de la Sante et de la Recherche Medicale (INSERM), U1188 - Université de La Réunion, Saint-Denis, France
刊名: Scientific Reports, 2019, Vol.9 (7), pp.569-579
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-019-47109-4
英文摘要: Abstract(#br)Kidney function is altered by age together with a declined filtration capacity of 5–10% per decade after 35 years. Renal aging shares many characteristics with chronic kidney disease. Plasma levels of the bioactive peptide apelin also decline with age and apelin has been shown to be protective in chronic kidney disease. Therefore we evaluated whether apelin could also improve aging-induced renal lesions and function in mice. Since urine is for the major part composed of proteins and peptides originating from the kidney, we first studied apelin-induced changes, in the aging urinary peptidome. Despite the recently published age-associated plasma decrease of apelin, expression of the peptide and its receptor was increased in the kidneys of 24 months old mice. Twenty-eight days...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)