Coenzyme Q10 — A new player in the treatment of heart failure?
作者: Jerzy JankowskiKatarzyna KorzeniowskaArtur CieślewiczAnna Jabłecka
作者单位: 1Department of Clinical Pharmacology,Poznan University of Medical Sciences,Poznań,Poland
刊名: Pharmacological Reports, 2016, Vol.68 (1), pp.1015-1019
来源数据库: Springer Nature Journal
DOI: 10.1016/j.pharep.2016.05.012
关键词: Coenzyme Q10Heart failureSupplementation
原始语种摘要: Abstract(#br)Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of Coenzyme Q10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can significantly reduce morbidity and mortality of heart failure patients in addition to guideline recommended pharmacotherapy.
全文获取路径: Springer Nature  (合作)
影响因子:1.965 (2012)