PhI(OAc) 2 -promoted umpolung acetoxylation of enamides for the synthesis of α-acetoxy ketones
作者: Ming ChenWei ZhangZhi-Hui RenWen-Yun GaoYao-Yu WangZheng-Hui Guan
作者单位: 1Northwest University
刊名: Science China Chemistry, 2017, Vol.60 (6), pp.761-768
来源数据库: Springer Nature Journal
DOI: 10.1007/s11426-016-0478-3
关键词: UmpolungEnamidesAcetoxylationHypervalent iodine reagentsΑ-acetoxy ketones
原始语种摘要: Umpolung is a fundamental concept in organic chemistry, which provides an alternative strategy for the synthesis of target compounds which were not easily accessible by conventional methods. Herein, a mild and efficient PhI(OAc)2-promoted umpolung acetoxylation reactions of enamides was developed for the synthesis of α-acetoxy ketones. The reaction tolerates a wide range of functional groups and affords α-acetoxy ketones in good to excellent yields. PhI(OAc)2 serves as a source of acetoxy in the reaction.
全文获取路径: Springer Nature  (合作)
影响因子:1.327 (2012)

  • acetoxy 醋酸基
  • synthesis 合成
  • reaction 反酌
  • functional 功能的
  • strategy 战略
  • easily 容易地
  • range 射程
  • alternative 可选择的
  • fundamental 基本的
  • iodine