A novel urinary biomarker predicts 1-year mortality after discharge from intensive care
作者: Esther Nkuipou-KenfackAgnieszka LatosinskaWen-Yi YangMarie-Céline FournierAlice BletBlerim MujajLutgarde ThijsElodie FeliotEtienne GayatHarald MischakJan A. StaessenAlexandre MebazaaZhen-Yu ZhangN. DeyeC. FauvauxA. MebazaaC. DamoiselD. PayenE. AzoulayA. S. MoreauL. JacobO. MarieM. WolfR. SonnevilleR. BronchardI. RennuitC. PaugamJ. P. MiraA. CariouA. TesnièresN. DufourN. AnguelL. GuérinJ. DuranteauC. RactM. LeoneB. PastèneT. Sharshar
作者单位: 1Mosaiques Diagnostics GmbH, Hannover, Germany
2Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Box 7001, 3000, Leuven, Belgium
3Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Department of Anesthesiology and Intensive Care, Saint Louis-Lariboisière – Fernand Widal University Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
5Université de Paris, Paris, France
6INSERM UMR-S 942 – MASCOT, Paris, France
7Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
刊名: Critical Care, 2020, Vol.24 (29), pp.849-856
来源数据库: Springer Nature Journal
DOI: 10.1186/s13054-019-2686-0
关键词: BiomarkerIntensive care medicineHeart failureMortalityUrinary proteomics
英文摘要: Abstract(#br)Rationale(#br)The urinary proteome reflects molecular drivers of disease. Objectives(#br)To construct a urinary proteomic biomarker predicting 1-year post-ICU mortality. Methods(#br)In 1243 patients, the urinary proteome was measured on ICU admission, using capillary electrophoresis coupled with mass spectrometry along with clinical variables, circulating biomarkers (BNP, hsTnT, active ADM, and NGAL), and urinary albumin. Methods included support vector modeling to construct the classifier, Cox regression, the integrated discrimination (IDI), and net reclassification (NRI) improvement, and area under the curve (AUC) to assess predictive accuracy, and Proteasix and protein-proteome interactome analyses. Measurements and main results(#br)In the discovery (deaths/survivors,...
全文获取路径: Springer Nature  (合作)
影响因子:4.718 (2012)