Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth
早产儿和营养对肠道微生物素发育和早产儿生长的影响
作者: Alex GrierXing QiuSanjukta BandyopadhyayJeanne Holden-WiltseHaeja A. KesslerAnn L. GillBrooke HamiltonHeidie HuyckSara MisraThomas J. MarianiRita M. RyanLori ScholerKristin M. ScheibleYi-Horng LeeMary T. CasertaGloria S. PryhuberSteven R. Gill
作者单位: 10000 0004 1936 9166, grid.412750.5, Genomics Research Center, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
20000 0004 1936 9166, grid.412750.5, Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
30000 0004 1936 9166, grid.412750.5, Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, 14642, Rochester, NY, USA
40000 0004 1936 9166, grid.412750.5, Division of Neonatology, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
50000 0004 1936 9166, grid.412750.5, Division of Infectious Disease, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
60000 0004 1936 9166, grid.412750.5, Pediatric Molecular and Personalized Medicine Program, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
70000 0001 2189 3475, grid.259828.c, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
80000 0000 9891 8434, grid.412225.2, Division of Pediatric Surgery, Department of Surgery, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA
90000 0001 2264 7217, grid.152326.1, Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA
刊名: Microbiome, 2017, Vol.5 (1), pp.810-820
来源数据库: Springer Nature Journal
DOI: 10.1186/s40168-017-0377-0
关键词: Preterm infantsGut microbiotaPhase transitionMeconiumNutritionInfant growth
英文摘要: Abstract(#br)Background(#br)Identification of factors that influence the neonatal gut microbiome is urgently needed to guide clinical practices that support growth of healthy preterm infants. Here, we examined the influence of nutrition and common practices on the gut microbiota and growth in a cohort of preterm infants. Results(#br)With weekly gut microbiota samples spanning postmenstrual age (PMA) 24 to 46 weeks, we developed two models to test associations between the microbiota, nutrition and growth: a categorical model with three successive microbiota phases (P1, P2, and P3) and a model with two periods (early and late PMA) defined by microbiota composition and PMA, respectively. The more significant associations with phase led us to use a phase-based framework for the majority of...
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:

×