Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes
作者: Areti Angeliki VeronikiElise CogoPatricia RiosSharon E. StrausYaron FinkelsteinRyan KealeyEmily ReynenCharlene SoobiahKednapa ThavornBrian HuttonBrenda R. HemmelgarnFatemeh YazdiJennifer D’SouzaHeather MacDonaldAndrea C. Tricco
作者单位: 1St. Michael’s Hospital
2University of Toronto
3The Hospital for Sick Children
4University of Ottawa
5The Ottawa Hospital
6Institute of Clinical and Evaluative Sciences (ICES uOttawa)
7Center for Practice Changing Research, The Ottawa Hospital – General Campus
8University of Calgary
刊名: BMC Medicine, 2017, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12916-017-0845-1
关键词: Network meta-analysisSystematic reviewEpilepsyFetusPregnancyAdverse effectsAntiepileptic drugsCongenital malformationsMiscarriageKnowledge synthesis
英文摘要: Pregnant women with epilepsy frequently experience seizures related to pregnancy complications and are often prescribed anti-epileptic drugs (AEDs) to manage their symptoms. However, less is known about the comparative safety of AED exposure in utero. We aimed to compare the risk of congenital malformations (CMs) and prenatal outcomes of AEDs in infants/children who were exposed to AEDs in utero through a systematic review and Bayesian random-effects network meta-analysis.
原始语种摘要: Pregnant women with epilepsy frequently experience seizures related to pregnancy complications and are often prescribed anti-epileptic drugs (AEDs) to manage their symptoms. However, less is known about the comparative safety of AED exposure in utero. We aimed to compare the risk of congenital malformations (CMs) and prenatal outcomes of AEDs in infants/children who were exposed to AEDs in utero through a systematic review and Bayesian random-effects network meta-analysis.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:6.679 (2012)

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关键词翻译
关键词翻译
  • epileptic 癫痫
  • congenital 先天的
  • prenatal 产前的
  • pregnancy 妊娠
  • review 复审
  • analysis 分析
  • drugs 药品
  • systematic 有系统的
  • epilepsy 癫痫
  • safety 安全