Early PET imaging with [68]Ga-PSMA-11 increases the detection rate of local recurrence in prostate cancer patients with biochemical recurrence
作者: Christian UprimnyAlexander Stephan KroissJosef FritzClemens DecristoforoDorota KendlerElisabeth von GuggenbergBernhard NilicaJohanna Maffey-SteffanGianpaolo di SantoJasmin BekticWolfgang HorningerIrene Johanna Virgolini
作者单位: 1Medical University Innsbruck
刊名: European Journal of Nuclear Medicine and Molecular Imaging, 2017, Vol.44 (10), pp.1647-1655
来源数据库: Springer Journal
DOI: 10.1007/s00259-017-3743-z
关键词: 68Ga-PSMA-11 PET/CTProstate canceerBiochemical relapseLocal recurrenceEarly PET imaging
英文摘要: PET/CT using 68Ga-labelled prostate-specific membrane antigen PSMA-11 (HBEDD-CC) has emerged as a promising imaging method in the diagnostic evaluation of prostate cancer (PC) patients with biochemical recurrence. However, assessment of local recurrence (LR) may be limited by intense physiologic tracer accumulation in the urinary bladder on whole-body scans, normally conducted 60 min post-tracer injection (p.i.). It could be shown on early dynamic imaging studies that 68Ga-PSMA-11 uptake in PC lesions occurs earlier than tracer accumulation in the urinary bladder. This study aims to investigate whether early static PET acquisition increases detection rate of local recurrence on 68Ga-PSMA-11 PET/CT in comparison to PET imaging 60 min p.i..
原始语种摘要: PET/CT using 68Ga-labelled prostate-specific membrane antigen PSMA-11 (HBEDD-CC) has emerged as a promising imaging method in the diagnostic evaluation of prostate cancer (PC) patients with biochemical recurrence. However, assessment of local recurrence (LR) may be limited by intense physiologic tracer accumulation in the urinary bladder on whole-body scans, normally conducted 60 min post-tracer injection (p.i.). It could be shown on early dynamic imaging studies that 68Ga-PSMA-11 uptake in PC lesions occurs earlier than tracer accumulation in the urinary bladder. This study aims to investigate whether early static PET acquisition increases detection rate of local recurrence on 68Ga-PSMA-11 PET/CT in comparison to PET imaging 60 min p.i..
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关键词翻译
关键词翻译
  • recurrence 循环
  • prostate 前列腺
  • PET PagE frame Table
  • imaging 图像形成
  • biochemical 生物化学的
  • bladder 膀胱
  • urinary 尿的
  • cancer 癌症
  • tracer 示踪物
  • detection 探测