Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial
作者: Darja KarpovaSusanne BräuningerEliza WiercinskaAriane KrämerBelinda StockJochen GraffHans MartinAchim WachChristophe EscotGarry DouglasBarbara RomagnoliEric ChevalierKlaus DembowskiLeon HooftmanHalvard Bonig
作者单位: 1Institute Frankfurt
2Washington University Medical School
3Goethe University
4Polyphor Ltd
5University of Washington
刊名: Journal of Translational Medicine, 2017, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12967-016-1107-2
关键词: PEM-technologyCXCR4MobilizationTransplantationApheresisStem cellPlerixaforG-CSFClinical trialPlasmacytoid dendritic cell
英文摘要: Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing mobilization with a peptidic CXCR4 antagonist POL6326 (balixafortide) vs. G-CSF.
原始语种摘要: Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing mobilization with a peptidic CXCR4 antagonist POL6326 (balixafortide) vs. G-CSF.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.459 (2012)

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关键词翻译
关键词翻译
  • hematopoietic 补血药
  • escalation 逐步升级
  • trial 试验
  • novel 长篇小说
  • healthy 健康的
  • dendritic 师状的
  • alternatives 代替案
  • mobilization 活化
  • results 成果
  • antagonist 对抗剂