PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival
作者: Heli RepoNatalia GurvitsEliisa LöyttyniemiMarjukka NykänenMinnamaija LintunenHenna KarraSamu KurkiTeijo KuopioKati TalvinenMirva SöderströmPauliina Kronqvist
作者单位: 1University of Turku and Turku University Hospital
2University of Turku
3University of Jyväskylä and Department of Pathology, Central Finland Health Care District
4Department of Pathology, Pori Central Hospital
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-017-3694-6
关键词: PTTG1IPPBFImmunohistochemistryBreast cancerPrognosis
英文摘要: PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin from the cell cytoplasm to the nucleus, allowing the interaction between separase and securin. PTTG1IP overexpression has been previously observed in malignant disease, e.g. in breast carcinoma. However, the prognostic value of PTTG1IP in breast carcinoma patients has not previously been revealed.
原始语种摘要: PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin from the cell cytoplasm to the nucleus, allowing the interaction between separase and securin. PTTG1IP overexpression has been previously observed in malignant disease, e.g. in breast carcinoma. However, the prognostic value of PTTG1IP in breast carcinoma patients has not previously been revealed.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • breast 胸部
  • protein 蛋白质
  • survival 生存
  • interacting 相克的
  • cancer 癌症
  • carcinoma 癌症
  • anaphase 后期
  • oncogenic 致癌的
  • prognostic 预测的
  • malignant 恶性的