Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells
作者: Shaowei QiuShuang LiuTengteng YuJing YuMin WangQing RaoHaiyan XingKejing TangYinchang MiJianxiang Wang
作者单位: 1Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College (CAMS & PUMC)
2Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-017-3787-2
关键词: IASPPSertad1P53ApoptosisLeukemic cell
英文摘要: As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can bind with iASPP in our previous study by two-hybrid screen.
原始语种摘要: As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can bind with iASPP in our previous study by two-hybrid screen.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • leukemic 白血病的
  • leukemia 白血病
  • cells 麻风细胞
  • interact 交互作用
  • oncogene 肿瘤基因
  • nuclei 
  • hindering 妨碍
  • screen 筛子
  • entrance 入口
  • function 函数