Striking the right immunological balance prevents progression of tuberculosis
作者: Shachi Pranjal VyasRitobrata Goswami
作者单位: 1IIT Kharagpur
刊名: Inflammation Research, 2017, Vol.66 (12), pp.1031-1056
来源数据库: Springer Journal
DOI: 10.1007/s00011-017-1081-z
关键词: TuberculosisMycobacterium tuberculosisMacrophagesT cellsGranulomataAutophagyImmunopathologyInflammationCytokinesChemokinesAnti-mycobacterial therapies
英文摘要: Tuberculosis (TB) caused by infection with Mycobacterium tuberculosis (Mtb) is a major burden for human health worldwide. Current standard treatments for TB require prolonged administration of antimycobacterial drugs leading to exaggerated inflammation and tissue damage. This can result in the reactivation of latent TB culminating in TB progression. Thus, there is an unmet need to develop therapies that would shorten the duration of anti-TB treatment and to induce optimal protective immune responses to control the spread of mycobacterial infection with minimal lung pathology.
原始语种摘要: Tuberculosis (TB) caused by infection with Mycobacterium tuberculosis (Mtb) is a major burden for human health worldwide. Current standard treatments for TB require prolonged administration of antimycobacterial drugs leading to exaggerated inflammation and tissue damage. This can result in the reactivation of latent TB culminating in TB progression. Thus, there is an unmet need to develop therapies that would shorten the duration of anti-TB treatment and to induce optimal protective immune responses to control the spread of mycobacterial infection with minimal lung pathology.
全文获取路径: Springer  (合作)
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影响因子:1.964 (2012)

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关键词翻译
关键词翻译
  • tuberculosis 肺结核
  • immunological 免疫学的
  • Mycobacterium -ria
  • progression 级数
  • inflammation 炎症
  • immune 免疫的
  • reactivation 再活化
  • exaggerated 放大
  • balance 平衡
  • worldwide 世界的