GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk
作者: Margery A. ConnellyJames D. OtvosIrina ShalaurovaMartin P. PlayfordNehal N. Mehta
作者单位: 1Laboratory Corporation of America Holdings (LabCorp)
2National Institutes of Health
刊名: Journal of Translational Medicine, 2017, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12967-017-1321-6
关键词: Nuclear magnetic resonance spectroscopyGlycAInflammationCardiovascular disease
英文摘要: GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases. GlycA is unique in its composite nature, reflecting both increased glycan complexity and circulating acute phase protein levels during local and systemic inflammation. Recent studies of GlycA from cross-sectional, observational and interventional studies have been highly informative, demonstrating that GlycA is elevated in acute and chronic inflammation, predicts death in healthy individuals and is associated with disease severity in patients with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and lupus. Moreover, following treatment with biological therapy...
原始语种摘要: GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases. GlycA is unique in its composite nature, reflecting both increased glycan complexity and circulating acute phase protein levels during local and systemic inflammation. Recent studies of GlycA from cross-sectional, observational and interventional studies have been highly informative, demonstrating that GlycA is elevated in acute and chronic inflammation, predicts death in healthy individuals and is associated with disease severity in patients with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and lupus. Moreover, following treatment with biological therapy...
全文获取路径: Springer  (合作)
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影响因子:3.459 (2012)

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关键词翻译
关键词翻译
  • inflammation 炎症
  • systemic 系统的
  • disease 
  • psoriasis 干癣
  • chronic 延续很长的
  • rheumatoid 患风湿病的
  • novel 长篇小说
  • inflammatory 激怒的
  • severity 严重性
  • lupus 豺狼座