Standardization of platelet releasate products for clinical applications in cell therapy: a mathematical approach
作者: Francesco AgostiniJerry PoleselMonica BattistonElisabetta LombardiStefania ZanolinAlessandro Da PonteGiuseppe AstoriCristina DuranteMario Mazzucato
作者单位: 1CRO Aviano National Cancer Institute
2San Bortolo Hospital
刊名: Journal of Translational Medicine, 2017, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12967-017-1210-z
关键词: Growth factors from human plateletsReleasate standardizationMathematical algorithmCell therapyGood manufacturing practiceASC ex vivo expansion
英文摘要: Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterized by undesired variability. Pooling together single-donor products improves consistency, but the minimal pool sample size was never determined.
原始语种摘要: Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterized by undesired variability. Pooling together single-donor products improves consistency, but the minimal pool sample size was never determined.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.459 (2012)

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关键词翻译
关键词翻译
  • products 制品
  • applications 应用程序
  • approach 
  • manufacturing 制造
  • together 共同
  • practice 实践
  • undesired 不希望有的
  • algorithm 算法
  • expansion 膨胀
  • consistency 一致性